Start with a commutative unital ring $X$, and consider the collection $\mathcal{L}$ of all rings $R$ such that there exists a multiplicative subset $S \subset R$ where $R\left[S^{-1}\right] \cong X$. Is there necessarily an $R \in \mathcal{L}$ such that the only non-units of $R$ are $\pm 1$? I.e. is there a "best" un-localization of $X$? And is this $R$ going to be unique in any sense? Is every other ring $R' \in \mathcal{L}$ going to be some localization of $R$ too? Generally what is the structure of $\mathcal{L}$ for a given ring $X$? Is this question more interesting if we reformulate it for not-necessarily-unital rings instead?
Note that I'm aware this might be a poor question; I'm very much spit-balling ideas I've never considered before, this sort of "inverse problem" for localization, to see if it's meaningful and if folks have thought about it before.
I'm not sure about your more general question about the structure of $\mathcal L$ but any finite field not equal to $\Bbb F_2$ or $\Bbb F_3$ (or more generally any integral domain containing a finite field $F\neq\Bbb F_2,\Bbb F_3$) will give an example of a ring which does not have an "un-localization"