I calculated the Gauss curvature of a surface in $\mathbb{R}^3$ with two parameters, ($\rho$, $\phi$), from the first fundamental form $I = \text{sech}^2(\rho)(d\rho^2 +d\phi^2)$.
I got $K = 1$, which I believe indicates that the surface is a sphere. Is there a way I can check my result, or somehow recognise that it must be correct directly from the first fundamental form?
Your calculation is correct. You do have $K=1$. However, without information about the second fundamental form, you cannot deduce that the surface is a sphere. There are lots of surfaces with $K=1$. [Fancy fact: We only have one coordinate patch here. But if we know the surface is compact and smooth, then Liebmann's Theorem tells us it must be a sphere.]