Do either $~S_4^+(a)~=~\displaystyle\sum_{n=0}^\infty(n+a){2a\choose n}^4~$ or $~S_4^-(a)~=~\displaystyle\sum_{n=-2a}^\infty(n+a){2a\choose-n}^4~$ possess a meaningful closed form expression in terms of the general parameter a ?
Ramanujan provided the following result : $~S_4^-\Big(-\tfrac18\Big)~=~\dfrac1{\bigg[\Big(-\tfrac14\Big){\large!}\bigg]^2~\sqrt{8\pi}}~,~$ which would point to a possible closed form expression in terms of $~(2a)!~$ and/or $~(4a)!~$
For lesser values of the exponent, we have Dixon's identity :
$$\sum_{n=0}^\infty(-1)^n{2a\choose n}^3 ~=~ \sum_{n=-2a}^\infty(-1)^n{2a\choose-n}^3 ~=~ \cos(a\pi)~{3a\choose a,a},$$
and Vandermonde's identity :
$$\sum_{n=0}^\infty(-1)^n{2a\choose n}^2 ~=~ \sum_{n=-2a}^\infty(-1)^n{2a\choose-n}^2 ~=~ \cos(a\pi)~{2a\choose a},$$
$$\sum_{n=0}^\infty{a\choose n}^2 ~=~ \sum_{n=-a}^\infty{a\choose-n}^2 ~=~ {2a\choose a},$$
as well as the binomial theorem :
$$\sum_{n=0}^\infty{a\choose n}^1x^n ~=~ (1+x)^a,\qquad\sum_{n=-a}^\infty{a\choose-n}^1x^n ~=~ \Big(1+\tfrac1x\Big)^a.$$
$$S_4^-(a)~=~S_3^-(a)\cdot{4a\choose2a}~=~-\frac{\sin(2a\pi)}{2\pi}\cdot{4a\choose2a}$$
See Dougall's very well-poised summation formula; also, notice that both sides satisfy the same recursion formula.