How to prove that
$$S=\displaystyle \sum_{n=1}^{\infty} \frac{ H_{n/2}}{(2n+1)^3} \quad=\quad \frac{\pi^2G}{4}-\frac{21\zeta(3)\ln(2)}{8}+\frac{\pi^4}{64}+\frac{\Psi^{(3)}(\frac{1}{4})}{512}- \frac{\Psi^{(3)}(\frac{3}{4})} {512}$$
This problem was proposed by @Ahmad Bow but unfortunately it was closed as off-topic and you can find it here.
Any way, I tried hard on this one but no success yet. here is what I did:
Using the identity
$$H_{n/2}=H_n-n\int_0^1 x^{n-1}\ln(1+x)\ dx, \quad x\mapsto x^2$$
$$H_{n/2}=H_n-2n\int_0^1 x^{2n-1}\ln(1+x^2)\ dx$$
We can write
$$S=\sum_{n=0}^\infty\frac{H_n}{(2n+1)^3}-\int_0^1\frac{\ln(1+x^2)}{x}\sum_{n=0}^\infty \frac{2nx^{2n}}{(2n+1)^3}\ dx$$
where
\begin{align} \sum_{n=0}^\infty \frac{2nx^{2n}}{(2n+1)^3}&=\frac1x\sum_{n=0}^\infty \frac{x^{2n+1}}{(2n+1)^2}-\frac1x\sum_{n=0}^\infty \frac{x^{2n+1}}{(2n+1)^3}\\ &=\frac1{2x}\sum_{n=0}^\infty \frac{x^{n+1}}{(n+1)^2}(1+(-1)^n-\frac1{2x}\sum_{n=0}^\infty \frac{x^{n+1}}{(n+1)^3}(1+(-1)^n\\ &=\frac1{2x}\sum_{n=1}^\infty \frac{x^{n}}{n^2}(1-(-1)^n-\frac1{2x}\sum_{n=1}^\infty \frac{x^{n}}{n^3}(1-(-1)^n\\ &=\frac1{2x}\left(\operatorname{Li}_2(x)-\operatorname{Li}_2(-x)-\operatorname{Li}_3(x)+\operatorname{Li}_3(-x)\right) \end{align}
Therefore
$$S=\sum_{n=0}^\infty\frac{H_n}{(2n+1)^3}-\frac12\int_0^1\frac{\ln(1+x^2)}{x^2}\left(\operatorname{Li}_2(x)-\operatorname{Li}_2(-x)-\operatorname{Li}_3(x)+\operatorname{Li}_3(-x)\right)\ dx$$
The sum can be done using the following identity
$$ \sum_{n=1}^{\infty} \frac{H_{n}}{ (n+a)^{2}}= \left(\gamma + \psi(a) \right) \psi_{1}(a) - \frac{\psi_{2}(a)}{2} \, , \quad a >0.$$
Differentiate both sides with respect to $a$ then set $a=1/2$ we get
$$\sum_{n=0}^\infty\frac{H_n}{(2n+1)^3}=\frac{45}{32}\zeta(4)-\frac74\ln2\zeta(3)$$
and the question here is how to calculate the the remaining integral or a different way to tackle the sum $S$ ? Thanks
Cornel's way to make it easy. Replace the harmonic number in the numerator by Digamma function, using that $H_{n/2}= \psi(n/2+1)+\gamma$, and then splitting the series using the parity, we have
$$ S=\sum_{n=1}^{\infty} \frac{ \psi(n/2+1)+\gamma}{(2n+1)^3}=\sum_{n=1}^{\infty} \frac{ \psi(n+1)+\gamma}{(4n+1)^3}+\sum_{n=1}^{\infty} \frac{ \psi(n+1/2)+\gamma}{(4n-1)^3}$$ $$=\sum_{n=1}^{\infty} \frac{H_n}{(4n+1)^3}+\sum_{n=1}^{\infty} \frac{ 2H_{2n}-H_n-2\log(2)}{(4n-1)^3}$$ $$=\sum_{n=1}^{\infty} \frac{H_n}{(4n+1)^3}-\sum_{n=1}^{\infty} \frac{H_n}{(4n-1)^3}-2\log(2)\sum_{n=1}^{\infty} \frac{1}{(4n-1)^3}+2\sum_{n=1}^{\infty} \frac{H_{2n}}{(4n-1)^3},$$ and since the first two series are straightforward using Cornel's Master Theorem of Series from A master theorem of series and an evaluation of a cubic harmonic series, which is also given in the book, (Almost) Impossible Integrals, Sums, and Series, and then noting that
$$\sum_{n=1}^{\infty} \frac{H_{2n}}{(4n-1)^3}=\frac{1}{2}\left(\sum_{n=1}^{\infty} \frac{H_{n}}{(2n-1)^3}-\sum_{n=1}^{\infty} (-1)^{n-1} \frac{H_{n}}{(2n-1)^3}\right),$$
where for the first series we can use the same mentioned master theorem, and then the second one is already known in the form $\displaystyle \sum_{n=1}^{\infty} (-1)^{n-1} \frac{H_{n}}{(2n+1)^3}$ (it's easy to rearrange the series according to our needs), and you may find its value here together with a solution in comments, we're done.
End of story.