Conjectures that have been disproved with extremely large counterexamples?

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I just came back from my Number Theory course, and during the lecture there was mention of the Collatz Conjecture.

I'm sure that everyone here is familiar with it; it describes an operation on a natural number – $n/2$ if it is even, $3n+1$ if it is odd.

The conjecture states that if this operation is repeated, all numbers will eventually wind up at $1$ (or rather, in an infinite loop of $1-4-2-1-4-2-1$).

I fired up Python and ran a quick test on this for all numbers up to $5.76 \times 10^{18}$ (using the powers of cloud computing and dynamic programming magic). Which is millions of millions of millions. And all of them eventually ended up at $1$.

Surely I am close to testing every natural number? How many natural numbers could there be? Surely not much more than millions of millions of millions. (I kid.)

I explained this to my friend, who told me, "Why would numbers suddenly get different at a certain point? Wouldn't they all be expected to behave the same?"

To which I said, "No, you are wrong! In fact, I am sure there are many conjectures which have been disproved by counterexamples that are extremely large!"

And he said, "It is my conjecture that there are none! (and if any, they are rare)".

Please help me, smart math people. Can you provide a counterexample to his conjecture? Perhaps, more convincingly, several? I've only managed to find one! (Polya's conjecture). One, out of the many thousands (I presume) of conjectures. It's also one that is hard to explain the finer points to the layman. Are there any more famous or accessible examples?

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Another example: Euler's sum of powers conjecture, a generalization of Fermat's Last Theorem. It states:
If the equation $\sum_{i=1}^kx_i^n=z^n$ has a solution in positive integers, then $n \leq k$ (unless $k=1$). Fermat's Last Theorem is the $k=2$ case of this conjecture.

A counterexample for $n=5$ was found in 1966: it's
$$ 61917364224=27^5+84^5+110^5+133^5=144^5 $$ The smallest counterexample for $n=4$ was found in 1988:
$$ 31858749840007945920321 = 95800^4+217519^4+414560^4=422481^4 $$ This example used to be even more useful in the days before FLT was proved, as an answer to the question "Why do we need to prove FLT if it has been verified for thousands of numbers?" :-)

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The wikipedia article on the Collatz conjecture gives these three examples of conjectures that were disproved with large numbers:

Polya conjecture.

Mertens conjecture.

Skewes number.

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The first example which came to my mind is the Skewes' number, that is the smallest natural number n for which π(n) > li(n). Wikipedia states that now the limit is near e727.952, but the first estimation was much higher.

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A famous example that is not quite as large as these others is the prime race.

The conjecture states, roughly: Consider the first n primes, not counting 2 or 3. Divide them into two groups: A contains all of those primes congruent to 1 modulo 3 and B contains those primes congruent to 2 modulo 3. A will never contain more numbers than B. The smallest value of n for which this is false is 23338590792.

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I heard this story from Professor Estie Arkin at Stony Brook (sorry, I don't know what conjecture she was talking about):

For weeks we tried to prove the conjecture (without success) while we left a computer running looking for counter-examples. One morning we came in to find the computer screen flashing: "Counter-example found". We all thought that there must have been a bug in the algorithm, but sure enough, it was a valid counter-example.

I tell this story to my students to emphasize that "proof by lack of counter-example" is not a proof at all!


[Edit] Here was the response from Estie:

It is mentioned in our paper:
Hamiltonian Triangulations for Fast Rendering
E.M. Arkin, M. Held, J.S.B. Mitchell, S.S. Skiena (1994). Algorithms -- ESA'94, Springer-Verlag, LNCS 855, J. van Leeuwen (ed.), pp. 36-47; Utrecht, The Netherlands, Sep 26-28, 1994.

Specifically section 4 of the paper, that gives an example of a set of points that does not have a so-called "sequential triangulation".

The person who wrote the code I talked about is Martin Held.

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For an old example, Mersenne made the following conjecture in 1644:

The Mersenne numbers, $M_n=2^n − 1$, are prime for n = 2, 3, 5, 7, 13, 17, 19, 31, 67, 127 and 257, and no others.

Pervushin observed that the Mersenne number at $M_{61}$ is prime, so refuting the conjecture.

$M_{61}$ is quite large by the standards of the day: 2 305 843 009 213 693 951.

According to Wikipedia, there are 51 known Mersenne primes as of 2023.

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Another class of examples arise from diophantine equations with huge minimal solutions. Thus the conjecture that such an equation is unsolvable in integers has only huge counterexamples. Well-known examples arise from Pell equations, e.g. the smallest solution to the classic Archimedes Cattle problem has 206545 decimal digits, namely 77602714 ... 55081800.

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I don't know if I would consider this accessible or 'large', but the counterexample of Adyan to the famous General Burnside Problem in group theory requires an odd exponent greater than or equal to 665. The "shorter" counterexample (proof) due to Olshanskii requires an exponent greater than $10^{10}$. The reason for the large number in the latter proof is essentially due to 'large scale' consequences of Gauss-Bonnet theorem for certain planar graphs expressing relations in groups. It may be that a finer analysis can show that a counterexample can occur at exponent as low as 5, but this is still not known.

This is probably essentially different than what you are asking, since we aren't forced to consider 665 because the cases 1-664 are known to be true. I thought it may be fun to point out, here, though!

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I was so pissed after testing one of my own conjectures that I remembered this question and wanted to post it here.

I conjectured after numerical observations that for every prime p, and integers $k \ge 1, n \ge 1$, that $$ p^k \, || 2^n-1 \quad \Longleftrightarrow \quad p^{k-1} \, || \, n \quad and \quad O(2,p) \, |\, n, $$ where $O(2,p)$ is the least integer $m$ such that $2^m \equiv 1 \pmod p$, and $||$ stands for exact division (i.e. $a^k \, | \, m$ but $a^{k+1} \, \nmid \, m$ is written $p^k \, || \, m$). This conjecture happens to be true for the first $180$ primes and the first $3000$ multiples of $O(2,p)$ (when $n$ is not a multiple of $O(2,p)$ we already know what happens). But it so happens that $1093$ is prime, that $O(2,1093) = 364$ and $2^{364} \equiv 1 \pmod {1093^2}$, so that the statement above is not true when $k=1$, $n = 364$ and $p=1093$ because the division on the LHS is not exact.

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It is well known that Goldbach's conjecture is one of the oldest unsolved problems in mathematics. A counterexample if it exists it will be a number greater than $4\cdot10^{18}$.

What is not well-known is that Goldbach made another conjecture which turned out to be false. The conjecture was

All odd numbers are either prime, or can be expressed as the sum of a prime and twice a square.

The first of only two known counterexamples is $5777$ (The second being $5993$).

This number is not "extremely large" for today's data but surely it was on 1752 when Goldbach proposed this conjecture in a letter to Euler who failed to find the counterexample. It was found a century later in 1856 by Moritz Abraham Stern (see this). The prime numbers that cannot be written as a sum of a (smaller) prime and twice a square are called Stern primes. It is believed that there are only finitely many Stern primes.