Is there a cover of the disk in the plane by three open connected sets $U_1, U_2, U_3$ such that any two of these sets have nonempty intersection, but the triple intersection $U_1 ∩ U_2 ∩ U_3$ is empty?
Clearly this is possible for the disk's boundary, i.e. a circle, but it does not seem possible for the disk itself. I can tell that such a cover will not be a good cover, since this would imply the disk is homotopically equivalent to the covering's nerve, in this case a triangle.
No it is not true. Mayer-Vietoris sequence for homology will give a contradiction.
Suppose $D^2 = U\cup V\cup W$ where $U,V,W$ are connected open set. Let $Z=V\cup W$ is connected open set . Then the fact that these three open sets have no common point implies $Z\cap U$ has at least two open component ( since $U\cap V$ and $U\cap W$ are non-empty). Now Mayer-Vietories long exact sequence for the pair $(U,Z)$
$\cdots \to H_1(D^2)\to H_0(U\cap Z)\to H_o(U)\oplus H_0(Z)\to H_0(D^2)\to 0$
=
$\cdots \to 0\to H_0(U\cap Z) \to \mathbb{Z\oplus Z} \to \mathbb{Z}\to 0$
Since the above s.e.s splits, this implies $H_o(U\cap Z)= \mathbb Z$ which is a contradiction.
EDIT: Actually the above solution tells us that not only for $D^2$ but for any simply connected space, we cannot cover it by using $3$ open connected sets which satisfy the given property.