Let $\mathcal{H}_2$ be a separable Hilbert space and $(T,D(T))$ be an operator in $\mathcal{H}_2$ such that there exists a Hilbert basis $(e_n)_{n\in \mathbb{N}}$ of $\mathcal{H}_2$ with $e_n \in D(T)$ for any $n \in \mathbb{N}$ and $Te_n = \mu_n e_n$.
a) Describe the closure $\bar{T}$ of $T$.
b) Describe the adjoint $T^*$ of $T$.
c) Suppose that $\mu_n \in \mathbb{R}$ for any $n \in \mathbb{N}$. Prove that $\bar{T}$ is self-adjoint.
Since $\mathcal{H}_2$ is a Hilbert space, its norm must be continuous, bounded and the space must be complete. Therefore for each element $Tx \in \mathcal{H}_2$ with $x \in D(T)$:
\begin{align*} ||{Tx}||_{\mathcal{H}_2} = ||{\sum_{n=1}^\infty\,h_ne_n}||_{\mathcal{H}_2} \leq \sum_{n=1}^\infty\,||{h_ne_n}||_{\mathcal{H}_2} \leq c_{\mathcal{H}_2}\,\sup_{n\in\mathbb{N}}\,||{h_ne_n}|| < \infty \end{align*} Therefore $T$ is limited. We can also formulate $x \in D(T)$ using the base $(e_n)_n$: $x = \sum_{n=1}^\infty \, b_ne_n$. Therefore, the $T$ operator works as follows: \begin{align} Tx = \sum_{n=1}^\infty\, b_n \, Te_n = \sum_{n=1}^\infty\,b_n\mu_ne_n \end{align} Let us now consider the following: \begin{align*} ||{Tx}||_{\mathcal{H}_2} &= ||{\sum_{n=1}^\infty\,b_n\mu_ne_n}||_{\mathcal{H}_2} \leq \sum_{n=1}^\infty \, ||{b_n\mu_ne_n}||_{\mathcal{H}_2} = \sum_{n=1}^\infty |\mu_n|\,||{b_ne_n}||_{\mathcal{H}_2} \\ &\leq \sup_{n\in\mathbb{N}}\,|\mu_n|\cdot \sum_{n=1}^\infty\,||{b_ne_n}||_{\mathcal{H}_2} = ||{\mu_n}||_\infty\cdot\sum_{n=1}^\infty\,||{b_ne_n}||_{\mathcal{H}_2} \leq ||{\mu_n}||_\infty\cdot c_{\mathcal{H}_2}\,\sup_{n\in\mathbb{N}}\,||{b_ne_n}||_{\mathcal{H}_2} \\ & \leq ||{\mu_n}||_\infty\cdot c_{\mathcal{H}_2}\,\sup_{n\in\mathbb{N}}\,|b_n|\,||{e_n}||_{\mathcal{H}_2}\,. \end{align*} Since $||{Tx}||_{\mathcal{H}_2}$ must be $< \infty$, it follows that $||{\mu_n}||_\infty < \infty$. It is also linear: \begin{align} &T(\lambda x) = \sum_{n=1}^\infty\, \lambda b_n \, Te_n = \lambda\,Tx, \\ &T(x+y) = \sum_{n=1}^\infty\, \lambda (b_n+c_n) \, Te_n = \sum_{n=1}^\infty\, b_n\,Te_n + \sum_{n=1}^\infty\, c_n\,Te_n= Tx + Ty \end{align} Thus $T \in \mathcal{L}(D(T),\mathcal{H}_1)$, and therefore equally continuous in $D(T)$. After the theorem of closed graph, the corresponding graph $G_T$ is a closed subspace. Finally $T$ is closed. Thus $T = \bar{T}$ follows.
Is this so far correct? And what do I do now? How do I determine the adjoint $T^*$?
No, there are several things that are incorrect.
I would recommend you to try again with the following more concrete example: $\mathcal{H}_2=\ell^2=\{(x_n)\mid \sum_n |x_n|^2<\infty\}$, $D(T)=\{(x_n)\mid x_n=0\text{ for all but finitely many }n\}$, $T(x_n)=(n x_n)$. Once you can solve this, it should be quite easy to tackle the more general case.