Determinants and Differential Equations Problem

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I have a question on my homework in Differential Equations and Linear Algebra that I'm not quite sure on. Here is the background given to describe the question and the one following it:

"[Here] we explore a relationship between determinants and solutions to a differential equation. The $3\times 3$ matrix consisting of solutions to a differential equation and their derivatives is called the Wronskian and, as we will see in later chapters, plays a pivotal role in the theory of differential equations."

This is the question following the description:

"Verify that $y_1(x)=\cos(2x), y_2(x)=\sin(2x), y_3(x)=e^x$ are solutions to the differential equation: $y'''-y''+4y'-4y=0$, and show that $\{\{y_1, y_2, y_3\},\{y_1', y_2', y_3'\},\{y_1'', y_2'', y_3''\}\}$ is nonzero on any interval."

Now I'm really just looking for an explanation on how I would show that it is nonzero on any interval. I completed the first part, I believe, by just taking up to the third derivative for each and plugging each set in to verify an identity of 0=0 at the end. I would then put the terms into the matrix which would give me:

$$\{\{\cos(2x), \sin(2x), e^x\}, \{-2\sin(2x), 2\cos(2x), e^x\}, \{-4\cos(2x), -4\sin(2x), e^x\}\}$$

So I've gotten this far and if anyone could point me in the right direction on where to go from here it would be greatly appreciated. Thanks guys.

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Calculating the Wronskian involves taking the determinant of the matrix you've calculated. The typical formula given looks like $$ \left| \begin{array}{ccc} a&b&c\\d&e&f\\g&h&i \end{array}\right| = a\left| \begin{array}{cc} e&f\\h&i \end{array}\right| - b\left| \begin{array}{cc} d&f\\g&i \end{array}\right| + c\left| \begin{array}{cc} d&e\\g&h \end{array}\right| $$ $$ = aei - afh - bdi + bfg + cdh - ceg.$$ When you calculate this for your matrix you'll get some function in $x$ (since each entry is a function in $x$). This function is the Wronskian, and you simply examine it to make sure it is never zero.

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$$\{\{\cos(2x), \sin(2x), e^x\}, \{-2\sin(2x), 2\cos(2x), e^x\}, \{-4\cos(2x), -4\sin(2x), e^x\}\}$$

This is a matrix. You're asked to prove there is no $x$ which makes the determinant of this matrix zero. $$\det\begin{bmatrix}\cos(2x) & \sin(2x) & e^x \\ -2\sin(2x) & 2\cos(2x) & e^x \\ -4\cos(2x) & -4\sin(2x) & e^x\end{bmatrix} = 0$$