In the accompanying figure, all seven contact points are tangential. It can be verified that if the areas of the major and minor circles, noted $A$ and $a$, are respectively equal to $8\pi$ and $2\pi$ then the area of the blue rectangle is equal to $7$.
Can you find without much work necessary and sufficient conditions between the areas $A$ and $a$ so that the area of the blue rectangle is an integer? Or would it be too difficult?

If the radii of the circles are $r$ and $R$, then the side of the big square is $s=(r+R)(1+\frac{\sqrt{2}}{2})$ and so the sides of the rectangle are $s-2r=R(1+\frac{\sqrt{2}}{2})+r(-1+\frac{\sqrt{2}}{2})$ and $s-2R=R(-1+\frac{\sqrt{2}}{2})+r(1+\frac{\sqrt{2}}{2})$, so (after the calculation) the area of the rectangle is:
$$-\frac{1}{2}R^2-\frac{1}{2}r^2+3Rr=\frac{-A-a+6\sqrt{Aa}}{2\pi}$$
Now, I presume you want $A=u\pi, a=v\pi$, so this area then becomes:
$$-\frac{u+v}{2}+3\sqrt{uv}$$
which gives you necessary and sufficient conditions: (a) $u,v$ are of the same parity; (b) $uv$ is a square.