The definition of convergence is : $\lim\limits_{n \to \infty}a_n =l \Rightarrow \lim\limits_{n \to \infty}a_n -l=0 $
So $\lim\limits_{n \to \infty}\frac{n^2 +1 }{4n -1} =\infty \Rightarrow \lim\limits_{n \to \infty}\frac{n^2 +1 }{4n -1} -\infty =0$
and we have to show that $ \forall n > X,|\frac{n^2 +1 }{4n -1} -\infty| < \epsilon $.
$$4n-1\leq 4n\quad\text{and}\quad n^2+1\geq n^2.$$ Therefore $$\frac{n^2+1}{4n-1}\geq \frac{n^2}{4n}=\frac{n}{4}.$$ Then, if $M>0$, if you take $N=\lfloor 4M\rfloor+1$, you have that $$\frac{n^2+1}{4n-1}>M$$ when $n\geq N$ what prove the claim.