If $X$ is a topological space and $p:E\rightarrow X$ is a function, is it possible for $E$ to have two distinct topologies each one making $p:E\rightarrow X$ a local homeomorphism?
Obs.: A local homeomorphism $f:A\rightarrow B$ between topological spaces is a function such that for every $a\in A$ there are open sets $U$ and $V$ in $A$ and $B$ such that $a\in U$ and $f\upharpoonright U:U\rightarrow V$ is a homeomorphism.
Yes. Consider $E=\{1,2,3,4\}$ and $X=\{1,2\}$. Let $p:E\to X$ be given by
$$p(1)=p(2)=1$$ $$p(3)=p(4)=2$$
Now put the antidiscrete topology on $X$: $\tau_X=\{\emptyset, X\}$. While on $E$ put these two topologies:
$$\tau_{E,1}=\big\{\emptyset, E, \{1,3\}, \{2,4\}\big\}$$ $$\tau_{E,2}=\big\{\emptyset, E, \{1,4\}, \{2,3\}\big\}$$
Note that $\tau_{E,1}\neq\tau_{E,2}$. But you can easily check that $p$ is a local homeomorphism in both of them.
Side note: these two topologies are distinct (as requested) but homeomorphic. An interesting question is whether we can find non-homeomorphic topologies. I don't know the answer to that.