Let $R$ be an integral domain, and $f\in R[x]$. Is it true that $f(rx+b)$ being irreducible implies that $f$ is irreducible for $r,b \in R$?
I know that this is true for $R= \mathbb R$ or $\mathbb C$. However, how do you prove it? Is it true in general for $R$ an integral domain?
This depends on a couple things. Firstly, it depends on the definition of irreducible you choose. Let $K$ be the fraction field of $R$.
Notes:
Now lets see how these definitions of irreducibility interact with coordinate changes.
Let's be a little more clear about these coordinate changes. You've defined them as $\phi_{a,b} : R[x]\to R[x]$ defined by $x\mapsto ax+b$. We want to understand for which $a,b\in R$, we have that for all $f$ irreducible (by one of the definitions above) $\phi_{a,b}(f)$ is also irreducible (by the same definition). I'll also assume that $a\ne 0$, since otherwise, it's hardly a coordinate change, so much as an evaluation.
Definition 1:
Proof.
If $a\in R^\times$, $\phi_{a,b}$ is invertible with inverse $\phi_{a^{-1},-b/a}$, and ring automorphisms preserve units and thus irreducibles by definition 1.
Conversely, if $a\not\in R^\times$, then $x-b$ is irreducible (by definition 1, since it is monic), and $(x-b)\mapsto ax$, and $ax$ is not irreducible, since $ax=a\cdot x$ and neither $a$ nor $x$ is a unit. $\blacksquare$
Definition 3:
Proof.
$a$ is a unit in $K$, so $\phi_{a,b}$ as a coordinate change on $K[x]$ preserves irreducibility according to definition 1, and thus it preserves irreducibility in $R[x]$ according to definition 3. $\blacksquare$
Definition 2:
This is the hard definition, although it is more common than definition 3. This is why I included definition 3 despite the fact that it is uncommon.
If $R$ is a UFD, then by the fact that all coordinate changes preserve irreducibility according to definition 3, and the fact that definitions 2 and 3 are equivalent, then we have that all coordinate changes preserve definition 2.
However, it's hard to say what happens when $R$ is not a UFD.
Consider $R=k[u,v,w]/(u^2-vw)$. Consider $ux^2+(v+w)x+u$. I claim that this is irreducible according to definition 2, since the leading coefficient is irreducible, but if we do the coordinate change $x\mapsto ux$, we have $$u^3x^2 + u(v+w)x+u = u(vwx^2+(v+w)x+1)=u(vx+1)(wx+1).$$
Thus it is not always true that all coordinate changes preserve irreducibility according to definition 2 if $R$ is not a UFD.
I don't have a precise answer to what happens in this case, but I think this is sufficient to answer your question, so I'll leave it here. Feel free to comment if I've been unclear.