The symbol $\sqrt{x}$ refers to the principal square root of $x$, which means it only refers to the positive square root. For example, $\sqrt{9}=3$, not $\pm3$.
In your example, we have $-\sqrt{100x^{20}y^{10}}$. The principal square root of $100x^{20}y^{10}$ is $|10x^{10}y^5|$ (which is $10x^{10}y^5$ if $y$ is positive (because a positive value of $y$ would make the entire expression positive) and $-10x^{10}y^5$ if $y$ is negative). Thus, $-\sqrt{100x^{20}y^{10}}=-|10x^{10}y^5|$
The symbol $\sqrt{x}$ refers to the principal square root of $x$, which means it only refers to the positive square root. For example, $\sqrt{9}=3$, not $\pm3$.
In your example, we have $-\sqrt{100x^{20}y^{10}}$. The principal square root of $100x^{20}y^{10}$ is $|10x^{10}y^5|$ (which is $10x^{10}y^5$ if $y$ is positive (because a positive value of $y$ would make the entire expression positive) and $-10x^{10}y^5$ if $y$ is negative). Thus, $-\sqrt{100x^{20}y^{10}}=-|10x^{10}y^5|$