Let $K$ be the field $\mathbb{C}$ of complex numbers and let $X$ be a scheme of finite type over $S=\operatorname{Spec(K)}$.
The set $X(K)=\hom_{Sch/S}(S, X)$ of $K$-rational points of $X$ carries a natural topology coming from the topology of $K$. E.g. if $X=\operatorname{Spec}(A)\subseteq \mathbb{A}_K^d$ is affine, then the set $\mathbb{A}_K^d(K)$ is given the topology of $K^d$ and the set $X(K)$ is given the the subspace topology.
Suppose $X$, $Y$, $Z$, $W$ are schemes of finite type over $S$ and $D=$ $$ \begin{array}{rcl} X &\to &Y\\ \downarrow && \downarrow\\ Z &\to& W \end{array} $$ is a pushout (resp. pullback) diagram in $Sch/S$. Is then $D(K)$ a pushout (resp. pullback) diagram of topological spaces?
If this is too hard to answer in general, I am also interested in the statement for affine schemes $Aff/S$ over $S$ instead of all schemes $Sch/S$ over $S$.
Yes, this is true for fiber products. See Proposition 3.1 of Brian Conrad's article "Weil and Grothendieck approaches to adelic points."