There exist endofunctors of $\mathbf{Set}$ that are deficient inasmuch as they lack an initial algebra. The canonical example is the covariant powerset functor (the initial algebra of $\mathcal{P}$, if it existed, would include the whole cumulative hierarchy).
Now let $\mathbf{Set}_{< \aleph_1}$ denote the category of countable sets. I'm curious to know if there exist endofunctors of $\mathbf{Set}_{< \aleph_1}$ that also lack an initial algebra. Since we can't take powersets while remaining in the countable realm, it will be interesting to see if anyone can find an example of such a thing.
Every endofunctor on $\mathbf{Set}_{< \aleph_1}$ has an initial algebra. To prove this, here's the key set-theoretical lemma:
From this lemma, we can deduce the following remarkable fact:
It then follows that any endofunctor on $\mathbf{Set}_{< \aleph_1}$ has an initial algebra by Adámek's theorem. Explicitly, we define $A_n=T^n(\emptyset)$ for each $n\in\mathbb{N}$. There are canonical maps $A_n\to A_{n+1}$ given by applying $T^n$ to the unique map $\emptyset\to T(\emptyset)$. Letting $A=\operatorname{colim} A_n$, we also have $A\cong\operatorname{colim} T(A_n)$ since $T(A_n)=A_{n+1}$ and this is compatible with the maps in the system. Since $T$ preserves sequential colimits, the canonical map $A\cong\operatorname{colim} T(A_n)\to T(A)$ is an isomorphism, and its inverse gives a $T$-algebra structure $T(A)\to A$ on $A$, which can be shown to be initial.