Eliminating $\mu$ for variance answer

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In a problem, I'm trying to find the variance, where $V[x]= E[(x- E[x])^2]$ and one of the things that I know is that $E[x]= \mu$, but my final answer cannot contain $\mu$. What information are you suppose to know/use to be able to substitute something in for $\mu$ so that it can be eliminated?