From this Question:
How does one find the closed form for $(1)?$
$$\sum_{k=0}^{n}(-4)^k\frac{{n+k \choose 2k}}{ak+b}=F(a,b)\tag1$$
$$\sum_{k=0}^{n}(-4)^k\frac{{n+k \choose n-k}}{ak+b}=F(a,b)\tag2$$
This one is from the Question:
$F(0,1)=(-1)^n(2n+1)$
We got these two:
$F(1,1)=\frac{(-1)^n}{n}$
$F(2,1)=\frac{(-1)^n}{2n+1}$
You can find a closed form as follow :
$$ F(a,b)=\left(\sum_{k=0}^n \int_0^1(-4t)^{ak+b-1}\binom{n+k}{2k}dt \right) $$
Finite sum
$$ F(a,b)=\left( \int_0^1\sum_{k=0}^n(-4t)^{ak+b-1}\binom{n+k}{n-k}dt \right) $$
Then using the coefficient extraction function $[X^i]$ for a given $i$.
\begin{align*} \sum_{k=0}^n(-4t)^{ak+b-1}\binom{n+k}{n-k} & = \sum_{k=0}^n(-4t)^{ak+b-1}[X^{n-k}](1+X)^{n+k} \\ & = \sum_{k=0}^n(-4t)^{ak+b-1}[X^n]z^k(1+X)^{n+k} \\ & = [X^n](1+X)^n(-t)^{a+b-1}\sum_{k=0}^n(-4^at^a)^{k}X^k(1+X)^{k} \\ & = [X^n](1+X)^n(-t)^{a+b-1}\dfrac{1-(-4^at^aX(1+X))^{n+1}}{1+4^at^aX(1+X)} \\ &= [X^n](1+X)^n(-t)^{a+b-1}\dfrac{1}{1+4^at^aX(1+X)} \\ &=[X^n](-t)^{a+b-1}\dfrac{(1+X)^{n-1}}{1+4^at^aX} \\ & = [X^n](-t)^{a+b-1}(1+X)^{n-1}\sum_{i=0}^\infty(-1)^i(4^at^aX)^i \\ & = (-t)^{a+b-1}\sum_{i=0}^\infty(-1)^i[X^{n-i}](1+X)^{n-1}(4^at^a)\\ & = (-t)^{a+b-1}\sum_{i=0}^\infty(-1)^i\binom{n-1}{i}(4^at^a)^i\\ & = (-t)^{a+b-1}(1-4^at^a)^{n-1}\\ \end{align*}
From here the exercise can be ended.
Credits
This answer is inspired from the work in the answer here : sum of binomial series with alternate terms.