I am asked to evaluate the integral by hand. I do not know how to start
$$\int_0^4\int_x^4\int_0^y\frac{6}{1 + 48z - z^3}\, dz\, dy\, dx$$
Note: This is a homework question. Explicit permission to seek help from others is given.
I do not see a suitable $u$-sub nor can I factor out $z$ for an easier integral.
Changing the order of integration does not seem to help either (i.e., to $dy\, dz\, dx$).
Even WolframAlpha can only show it is approximately equal to $4.859\,81$.
Symbolab says steps are not supported for this type of question.
Let $\mathcal{I}$ denote the value of the triple integral,
$$\mathcal{I}:=\int_{0}^{4}\mathrm{d}x\int_{x}^{4}\mathrm{d}y\int_{0}^{y}\mathrm{d}z\,\frac{6}{1+48z-z^{3}}.$$
Having a cubic function with non-nice roots in the denominator of the integrand usually guarantees you an algebraically induced headache if you attempt to solve the integral by brute force. Since this is a homework problem, and assuming your professor isn't an outright sadist, you can expect there to be some trick to solving the integral with a lot less effort.
Sure enough, by changing the order of integration, we can easily reduce the triple integral to a single-variable integral:
$$\begin{align} \mathcal{I} &=\int_{0}^{4}\mathrm{d}x\int_{x}^{4}\mathrm{d}y\int_{0}^{y}\mathrm{d}z\,\frac{6}{1+48z-z^{3}}\\ &=\int_{0}^{4}\mathrm{d}y\int_{0}^{y}\mathrm{d}x\int_{0}^{y}\mathrm{d}z\,\frac{6}{1+48z-z^{3}}\\ &=\int_{0}^{4}\mathrm{d}y\int_{0}^{y}\mathrm{d}z\int_{0}^{y}\mathrm{d}x\,\frac{6}{1+48z-z^{3}}\\ &=\int_{0}^{4}\mathrm{d}y\int_{0}^{y}\mathrm{d}z\,\frac{6y}{1+48z-z^{3}}\\ &=\int_{0}^{4}\mathrm{d}z\int_{z}^{4}\mathrm{d}y\,\frac{6y}{1+48z-z^{3}}\\ &=\int_{0}^{4}\mathrm{d}z\,\frac{48-3z^{2}}{1+48z-z^{3}}\\ &=\int_{1}^{129}\mathrm{d}u\,\frac{1}{u};~~~\small{1+48z-z^{3}=u}\\ &=\ln{\left(129\right)}.\blacksquare\\ \end{align}$$