Suppose that $\Omega \subseteq \mathbb R^n$ non-empty, open, and $n \ge 1$.
We have an increasing collection $(K_i)_{i \in \mathbb N}$ of compact subsets of $\Omega$ with union $\Omega$.
For $K \subset \Omega$ fixed and compact, is it necessarily the case that $K \subseteq K_i$ for $i$ sufficiently large?
I know that this is true when we have the constraint that $K_i \subseteq \mathrm{interior}(K_{i+1})$ for each $i \in \mathbb N$.
I am not convinced that this will be the case without this constraint, but I have had some trouble cooking up a counterexample.
I think one could arise if we took $K$ to have non-empty interior and $K_i$ to have empty interior for each $i$, by taking some pathological choice of $K_i$.
Take $\Omega=B((0,0),1)\subset \mathbb{R}^2$, $K_n$ the union of the closed annulus of inner radius $\dfrac{1}{n}$ and outer radius $1-\dfrac{1}{n}$ and $\{(0,0)\}$, which clearly are compact, increasing and whose union is $\Omega$.
If $K=\left\{\left(\dfrac{1}{n},0\right)\right\}_{n\geq 2}\cup \{(0,0)\},$ which is compact as it is a convergent sequence with its limit, then $K$ is never contained in any $K_i$.