We can see that $a=0$ makes expression $0$, similarly others make expression $0$.This implies that its factorization has $abc$ in it.I substituted $a+b+c=s$ tried to find remaining factors.From here I did not progress any further
Later I went on finding this on wolframalpha and it's factorization is $80abc(a^2+b^2+c^2)$. How can we get its factorization by hand without actually expanding whole thing?Is there any slick way?
It's $abcQ(a,b,c)$ where $Q(a,b,c)$ is a symmetric degree $2$ function: $$Q(a,b,c)=r(a^2+b^2+c^2)+s(ab+bc+ca).$$ We only need to test two values to find $r$ and $s$. $$Q(1,1,1)=\frac{3^5-1^5-1^5-1^5}1=240$$ and $$Q(1,1,-1)=\frac{1^5-3^5-(-1)^5-(-1)^5}{-1}=240.$$ So $3r+3s=3r-s=240$, leading to $s=0$ and $r=80$.