Factorize $(a+b+c)^5-(a+b-c)^5-(a+c-b)^5-(b+c-a)^5$

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We can see that $a=0$ makes expression $0$, similarly others make expression $0$.This implies that its factorization has $abc$ in it.I substituted $a+b+c=s$ tried to find remaining factors.From here I did not progress any further

Later I went on finding this on wolframalpha and it's factorization is $80abc(a^2+b^2+c^2)$. How can we get its factorization by hand without actually expanding whole thing?Is there any slick way?

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It's $abcQ(a,b,c)$ where $Q(a,b,c)$ is a symmetric degree $2$ function: $$Q(a,b,c)=r(a^2+b^2+c^2)+s(ab+bc+ca).$$ We only need to test two values to find $r$ and $s$. $$Q(1,1,1)=\frac{3^5-1^5-1^5-1^5}1=240$$ and $$Q(1,1,-1)=\frac{1^5-3^5-(-1)^5-(-1)^5}{-1}=240.$$ So $3r+3s=3r-s=240$, leading to $s=0$ and $r=80$.

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On

Let $a+b=x,\,a-b=y$ \begin{align*} (a + b + c)^5 - (a + b - c)^5 - (a + c - b)^5 - (b + c - a)^5=\\ (x+c)^5+(c-x)^5-(y+c)^5+(y-c)^5=\\ c^5 + 5 c^4 x + 10 c^3 x^2 + 10 c^2 x^3 + 5 c x^4 + x^5+\\ c^5 - 5 c^4 x + 10 c^3 x^2 - 10 c^2 x^3 + 5 c x^4 - x^5+\\ -c^5 - 5 c^4 y - 10 c^3 y^2 - 10 c^2 y^3 - 5 c y^4 - y^5+\\ -c^5 + 5 c^4 y - 10 c^3 y^2 + 10 c^2 y^3 - 5 c y^4 + y^5=\\ 20 c^3 (x^2-y^2)+10c(x^4-y^4)=\\ 20 c^3 (x-y)(x+y)+10c(x-y)(x+y)(x^2+y^2)=\\ 80 c^3 b a + 80 c b a (a^2+b^2)=\\ 80 abc(c^2+a^2+b^2) \end{align*}

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(Along Angina Seng's answer)

The given polynomial $p$ is homogeneous of degree $5$ and symmetric in $a$, $b$, $c$. Furthermore $$p=\bigl((a+b)+c)\bigr)^5-\bigl((a+b)-c\bigr)^5-\bigl((a-b)+c\bigr)^5+\bigl((a-b)-c\bigr)^5\ ,$$ hence $p$ is odd in each variable. It follows that $p=abc\ Q(a,b,c)$, where $Q$ is a symmetric homogeneous polynomial of degree $2$ which is even in each variable. It follows that $Q(a,b,c)=N(a^2+b^2+c^2)$ for a certain constant $N$. Letting $a=b=c=1$ gives $N=80$.