$H$ is a separable infinite-dimensional Hilbert space.
1- Find two self-adjoint operators on $H$ with spectrum $[0, 1]$ and empty point-spectrum that are not unitarily equivalent.
2- Find uncountably many self-adjoint operators on H with spectrum $[0, 1]$ and empty point-spectrum that are pairwise unitarily inequivalent.
I can refer to Is there an injective, self-adjoint operator on $\ell_2(\mathbb{Z})$ with spectrum $[0,1]$?
And to "Conway's A Course in Functional Analysis" section IX. 10 on 'Multiplicity Theory for Normal Operators: A Complete Set of Unitary Invariants' as mentioned in the comments by @Martin .
I am thinking toward using spectral measures, though I think that producing an uncountable family would be challenging, or obvious from the cardinality of the space of measures being larger than (or equal to) the uncountable $c$.
Concerning the first question, consider $L^2(0,1)$ and $L^2(0,1)\times L^2(0,1).$ These spaces are isometrically isomorphic, as both are separable Hilbert spaces. Let $T$ acts on $L^2(0,1)$ as $(Tf)(x)=xf(x)$ and $S$ acts on the second space as $S(f,g)(x)=(xf(x),xg(x)).$ Then $\sigma(T)=\sigma(S)=[0,1].$ The point spectra of both operators are empty.
The operator $T$ has a cyclic vector, namely $v(x)=1.$ By definition for a cyclic vector $v$ the linear span of all vectors $T^nv,$ $n\ge 0,$ is dense in the space. For our $T$ it follows from the Weierstrass theorem. On the other hand $S$ does not admit a cyclic vector. Indeed, assume $(f,g)$ is a cyclic vector for $S.$ Consider $(1,0)\in L^2(0,1)\times L^2(0,1).$ Therefore, there exists a sequence of polynomials $p_n(x),$ such that $p_n(S)(f,g)=(p_n(x)f(x), p_n(x)g(x))$ tends to $(1,0)$ in $L^2(0,1)\times L^2(0,1).$ Thus $p_n(x)f(x)$ tends to $1$ and $p_n(x)g(x)$ tends to $0$ in $L^2(0,1).$ There exists $a>0$ such that the set $A=\{x\,:\, |g(x)|>a\}$ has positive Lebesgue measure. Then $p_n(x)\chi_A(x)$ tends to $0$ and $p_n(x)f(x)\chi_A(x)$ tends to $\chi_A(x).$ This leads to a contradiction.
The operators $T$ and $S$ cannot be unitarily equivalent as the equivalence relation preserves the property of having a cyclic vector.