Find close expression for the sum $$S_{n,k}=\sum_{i=0}^{2n} (-1)^i \binom{n-1}{i} \binom{n+1}{k-i}.$$ For small $k$ I have got following \begin{align} &S_{n,0}=1,\\ &S_{n,1}=2,\\ &S_{n,2}=-n+2,\\ &S_{n,3}=-2n+2,\\ &S_{n,4}=\frac{(n-1)(n-4)}{2},\\ &S_{n,5}=(n-1)(n-2),\\ &S_{n,6}=-\frac{(n-1)(n-2)(n-6)}{6} \end{align}
What is the expression for $S_{n,k}$ for arbitrary $n,k$?
$$S_{n,k}=\sum_{i=0}^{2n} (-1)^i \binom{n-1}{i} \binom{n+1}{k-i}=\sum_{i=0}^{k} (-1)^i \binom{n-1}{i} \binom{n+1}{k-i}$$ Let $[x^j] f(x)$ denote the coefficient of $x^j$ in the expansion of $f(x)$. $$\large\therefore S_{n,k}=[x^k]\ \sum_{k=0}^{\infty}\sum_{i=0}^{k} (-1)^i \binom{n-1}{i} \binom{n+1}{k-i}x^k$$$$\large=[x^k]\ \bigg(\sum_{j=0}^{\infty}(-1)^j \binom{n-1}{j}x^j\bigg)\bigg(\sum_{j=0}^{\infty}\binom{n+1}{j}x^j\bigg)$$$$\large=[x^k]\ (1-x)^{n-1}(1+x)^{n+1}=[x^k]\ (1-x^2)^{n-1}(x^2+2x+1)$$
$$\LARGE \therefore S_{n,k}=\begin{cases} (-1)^{\frac{k}{2}}\Bigg(\binom{n-1}{\frac{k}{2}} - \binom{n-1}{\frac{k}{2}-1}\Bigg)& k\text{ is even} \\ 2(-1)^{\frac{k-1}{2}}\huge\binom{n-1}{\frac{k-1}{2}} & k\text{ is odd} \end{cases}$$ $\blacksquare$
Also see Cauchy product.