Find eigenvalues of the $(n+1) \times (n+1)$-matrix
$$ \left( \begin {array}{cccccccc} 0&0&0&0&0&0&-n&0\\ 0 &0&0&0&0&-(n-1)&0&1\\ 0&0&0&0&-(n-2)&0&2&0 \\ 0&0&0&\ldots&0&3&0&0\\ 0&0&-3&0&\ldots&0 &0&0\\ 0&-2&0&n-2&0&0&0&0\\ -1&0&n-1&0 &0&0&0&0\\ 0&n&0&0&0&0&0&0\end {array} \right) $$
I have tried for some small $n$ by hand and have got that for $n=3$ the eigenvalues are $1,-1,3,-3$, for $n=4$ eigenvalues are $0,2,-2,4,-4$. So I am conjectured than for arbitrary $n$ the eigenvalues are $n, n-2, n-4, \ldots, -n+2,-n.$
How to prove it?
Call your matrix $B_{n+1}$. Denote the Kac matrix of the same size by $$ A_{n+1}=\pmatrix{ 0&n\\ 1&0&n-1\\ &2&\ddots&\ddots\\ & &\ddots&\ddots&\ddots\\ & & &\ddots&0 &1\\ & & & & n &0}. $$ It is known that the spectrum of the Kac matrix is given by $$ \sigma(A_{n+1})=\{-n,\,-n+2,\,-n+4,\ldots,\,n-4,\,n-2,\,n\}. $$ We shall prove that $\sigma(A_{n+1})=\sigma(B_{n+1})$. Consequently (as the Kac matrix has distinct eigenvalues) the two matrices are similar to each other.
Here is our proof. First, $B_{n+1}^2$ is similar to $A_{n+1}^2$. In fact, if $D$ denotes the $(n+1)\times(n+1)$ diagonal matrix such that $d_{kk}=(-1)^{\lfloor(k-1)/2\rfloor}$ (i.e. $D=\operatorname{diag}(1,1,-1,-1,1,1,-1,-1,\ldots)$), a straightforward computation will show that $DB_{n+1}^2D=A_{n+1}^2$.
Thus $\sigma(B_{n+1}^2)=\sigma(A_{n+1}^2)$. Yet, as pointed out in the answer by Jean Marie, $B_{n+1}$ is similar to $-B_{n+1}$ via the reversal matrix (the mirror image of the identity matrix from left to right). Therefore, nonzero eigenvalues of $B_{n+1}$ must occur in pairs of the form $\pm\lambda$. Hence we have $\sigma(B_{n+1})=\sigma(A_{n+1})$, because the multiplicity of each nonzero eigenvalue of $A_{n+1}^2$ is exactly $2$.