If $n$ is an even natural number, then find $$\sum_{r=0}^n \left(\frac{(-1)^r}{\binom{n}{r}}\right)$$
I tried to solve the question using conventional method, by trying to use calculus, but I don't think that would be applicable here, because no binomial expansion (as far I as know) can give a coefficient in denominator hence I got stuck at it.
Using the beta function, Trif gives a proof in his paper
COMBINATORIAL SUMS AND SERIES INVOLVING INVERSES OF BINOMIAL COEFFICIENTS
to a slightly more general statement:
You question corresponds to the case when $m=0$.
See also the paper Alternating Sums of the Reciprocals of Binomial Coefficients for a more general discussion about the sum $$ T_n^{(l,m)}=\sum_{k=0}^n(-1)^kk^l\binom{m+n}{m+k}^{-1}. $$