The question is:

I thought of something like:
1st box: $(7-5)*(7+5)+50=74$ Yes!
2nd box: $(21-5)*(21+5)+50 =466$ Yes!
3rd box: $(21-7)*(21+7)+50=442$ No :( That's not an option.
I have tried almost everything but I can't still have seemed to figure out the answer.
Can someone please guide me on the steps to take.
Thanks a lot!
This seems likely:
$$7^2 + 5^2 = 74$$
$$5^2 + 21^2 = 466$$
$$21^2 + 7^2 = \boxed{490}$$