Let
$A(2,1,3), B(3,2,5), C(3,3,6), D(4,4,2)$
Find the volume $V$ of tetrahedron $ABCD$.
My Solution:
$\vec{AB} = (1, 1, 2), \vec{AC} = (1, 2, 3), \vec{AD} = (2, 3, -1)$
$$V=\begin{vmatrix}1&1&2\\1&2&3\\2&3&-1 \end{vmatrix}=-6$$
My question is: Is my solution right and can the volume be a negative number ?
If you did this using $B$ as the origin point (using $BA, BC, BD$ in that order) you would find $$ V=\frac16 \left| \pmatrix{-1&-1&-2\\0&1&1\\1&2&-3} \right| = \frac16 \cdot 6 $$ The determinant is equal to the volume only up to a factor of $\pm 1$; you can see this because if you change the order of any two of the sides, the determinant changes sign.
BTW, the $\frac16$ comes from $V = \frac13 Bh$ where $B$ is the area of the base, which is $\frac12 \ell w$.