$ABCD$ is a convex quadrilateral with $W, X, Y, Z, M$ and $N$ as the midpoints of $AB, BC, CD, DA,$ the diagonals $AC$ and $BD$ respectively. [Then, $WXYZ$ is a parallelogram with $K$ as the intersection point of its diagonals by Varignon's Theorem]
The 1st question is: “Will $K$ be the center of the circle using $MN$ as diameter?”
Line $BP$ is now drawn parallel to $AC$ cutting $DC$ produced at $P$. Let $Q$ be the midpoint of $DP$. $MN$ is produced to cut $BC$ at $R$.
The 2nd question is: “Is $RQ \parallel AD$?”
PS: The red and green lines are not perpendicular to each other.
Picture added to reflect @Aretino 's answer to the first question.


To the first question: yes, because: $$ K={1\over2}(W+Y)= {1\over2}\left({A+B\over2}+{C+D\over2}\right)= {1\over2}\left({A+C\over2}+{B+D\over2}\right)= {1\over2}(M+N). $$ More geometrically.
In triangle $CAD$, $M$ and $Y$ are midpoints of two sides, so we have $MY=AD/2$ and $MY\parallel AD$. In the same way, in triangle $ABD$ we have $NW=AD/2$ and $NW\parallel AD$. It follows that $MY=NW$ and $MY\parallel NW$, but then $MYNW$ is a parallelogram and its diagonals $MN$ and $WY$ have the same midpoint $K$.