$A(2 \cos \theta_1 , 2 \sin \theta_1)$ and $B(2 \cos \theta_2 , 2 \sin \theta_2)$ are two end points of a variable chord $AB$ of the circle, and $M$ is the midpoint of the chord. Suppose that the slope of the chord $AB$ is $\textbf{always}$ equal to $m$. Find the equation of the locus of $M$.
While trying to solve the problem I found that:
Equation of the circle is $x^2 + y^2 = 4$
Coordinates of chord midpoint $M$ are $\left( \cos \theta_1 + \cos \theta_2 , \sin \theta_1 + \sin \theta_2 \right)$
Slope of chord AB is $m = \dfrac{\sin \theta_2 - \sin \theta_1}{ \cos \theta_2 - \cos \theta_1}$
What should I do to get the solution: $x + my = 0$ ?
The slope of the line of midpoints must be $-\dfrac 1m$ and the line must contain the origin. So the equation is $y = -\dfrac 1mx$ or $x+my=0$
You know that \begin{align} M_{1,2} &= \left(\cos\theta_1 + \cos\theta_2 , \ \sin\theta_1 + \sin\theta_2 \right) \\ &= \left(2\cos\dfrac{\theta_1+\theta_2}{2} \cos\dfrac{\theta_1-\theta_2}{2} , \ 2\sin\dfrac{\theta_1+\theta_2}{2} \cos\dfrac{\theta_1-\theta_2}{2} \right) \end{align}
We also know that $M_0 =(0,0)$ is the midpoint of the line with slope $m$ that passes through the origin. The slope of the line through $M_0$ and $M_{1,2}$ is
$m' = \dfrac {2\sin\dfrac{\theta_1+\theta_2}{2}\cos\dfrac{\theta_1-\theta_2}{2}} {2\cos\dfrac{\theta_1+\theta_2}{2}\cos\dfrac{\theta_1-\theta_2}{2}} = \tan \dfrac{\theta_1+\theta_2}{2} $
You also know that
\begin{align} m &= \dfrac{\sin \theta_2 - \sin \theta_1} { \cos \theta_2 - \cos \theta_1} \\ &= \dfrac{ 2 \sin \dfrac{\theta_2 - \theta_1}{2} \cos \dfrac{\theta_2 + \theta_1}{2}} {-2 \sin \dfrac{\theta_2 - \theta_1}{2} \sin \dfrac{\theta_2 + \theta_1}{2}} \\ &= -\cot \dfrac{\theta_2 + \theta_1}{2} \end{align}
So, for all $\theta_1$ and $\theta_2$ that represent the angles corresponding to the endpoints of a line with slope $m$ intersecting the circle $x^2+y^2 = 4$, $m \cdot m' = -1$.
In other words, the locus of the bisectors is a line with slope $-\dfrac 1m$.