I was told in a topology class that if $Y$ is a closed $3$-manifold and $K$ is a null-homologous knot in $Y$, then $H_1(Y- \nu(K)) \cong H_1(Y) \oplus \mathbb{Z}$.
I'm trying to prove this assertion, but have been unsuccessful so far. I'm trying to work with the Mayer-Vietoris sequence applied to $Y-\nu(K)$ and a neighborhood of $K$, which will be isomorphic to $S^1 \times D^2$. The sequence gives
$$ \ldots \rightarrow H_2(Y) \rightarrow H_1(T^2) \rightarrow H_1(S^1 \times D^2) \oplus H_1(Y-\nu(K)) \rightarrow H_1(Y) \rightarrow \ldots $$
and the null-homologous condition tells us that $H_1(S^1 \times D^2) \rightarrow H_1(Y)$ is the zero map. If one could show that the connecting homomorphism were $0$, and there was a splitting of the resulting short exact sequence, then things would start to look good, but I'm not making any progressing towards that.
Note, as $K$ is null-homologous there exists some $3$-disk $D\subset Y$ which bounds the tubular neighourhood $\nu(K)$ of the knot $K$ (I think this is the case anyway - I could be wrong).This is incorrect! There exists null-homologous curves in $Y$ which are not bounded by a disk. The rest of this answer only applies if such a disk exists unfortunately.Now you only need to apply Mayer-Vietoris on the two subsets $\nu(Y\setminus D)$ and $D\setminus K$ whose intersection is homeomorphic to the sphere $S^2$.
It is well known that the first homology group of a knot complement $\mathbb{R}\setminus K$ is isomorphic to the integers $\mathbb{Z}$ (which can also be computed using a Mayer-Vietoris sequence), and so the calculation falls out quite nicely.