I would like to determine topological properties of $\mathbb R^8$ minus the set determined by the equation $$ \mathrm{det}\begin{pmatrix} a-a' & b-b'\\ c-c' & d-d' \end{pmatrix}=0$$ where $a,a',b,b',c,c',d,d'\in\mathbb R$.
How do I determine the homotopy type and how many connected components this space has? If this does not turn out to be a standard space, I would also like to determine (co)homology groups.
Let's denote your subset of $\mathbb R^8$ by $X$. Then there is a surjective continuous map $X\to GL(2,\mathbb R)$. The homotopy type of $GL(2,R)$ is two copies of $SL(2,R)$. Anyway, from this you can already tell that $X$ has at least two connected components! Now, I claim that $X$ is actually homotopy equivalent to $GL(2,R)$. Given an $8$-tuple in $X$, perform a homotopy where $(a,a')\mapsto (a-t,a'-t)$ for $t\in[0,a]$. Similarly do this for the other coordinates. This deformation retracts $X$ onto the space where $a=b=c=d=0$. Which is exactly $GL(2,R)$. As mentioned by user8268, $SL(2,R)\simeq S^1$, so $X\simeq S^1\cup S^1$.