I'd like to quantify over all cardinalities of sets.
My end goal is to make a category-theoretic arguement:
For all cardinalities of sets, in the category of sets with maps as morphisms: the subclass of objects with that given cardinality is closed under the class of isomorphisms, thereby forming a subcategory, for each set cardinality, where the morphisms are isomorphisms.
Can I quantify over a class that isn't a set?
Is there a good way to specify this class of cardinalities?
Is there a better way to go about this?
Your best bet is to prove something like $$\forall x \forall y(x \cong y \to |x| = |y|)$$ This is possible without quantifying over all cardinals (and, depending on your definition of cardinality, is a somewhat trivial result).
The fact that the class of sets of a given cardinality is closed under isomorphisms (bijections) is immediate: if $\kappa$ is a cardinal then, given any set $x$ of cardinality $\kappa$, if $y$ is another set and $x \cong y$ then $y$ also has cardinality $\kappa$, so lies in the class. (This is a very verbose rewording of the above expression though.)