We would like to compare the following two real 4 dimensional manifolds:
1)$M$=The tangent bundle of $S^{2}$
2)$N$= The total space of the canonical line bundle over $\mathbb{C}P^{1}\simeq S^{2}$
Are these two manifolds homeomorphic? Are they diffeomorphic?
Some remarks: They have the same homotopy type. So there is no an obvious obstruction for $M$ and $N$ to be homeomorphic. On the other hand $M$ is parallelizable. So it is natural to ask: Is $N$ parallelizable, too?
Is the later equivalent to ask " Is $TS^{2}\oplus \ell$ a trivial real 4 dimensional bundle. Where $\ell$ is the realification of the canonical line bundle?"?
You can prove that they're not homeomorphic by employing the same strategy as in the answer here.
If they were homeomorphic, so would be their one-point compactifications, and hence they would have the same cohomology. $TS^2$ has no embedded spheres with self-intersection number 1; the canonical line bundle does (the zero section!)
Another way of phrasing this: the intersection form $H_2(M) \otimes H_2(M) \to \Bbb Z$ is well-defined for any 4-manifold, compact or not, and is preserved by homeomorphisms. (If you want to be careful about this, you want to think about it in terms of non-compact Poincare duality. We can avoid that in the above situation b/c it's a special case, where the cohomology of the 1-pt compactification is that of $H^*(BV,SV)$.) So one just checks that for $TS^2$, $\iota(\sigma_0,\sigma_0) = 2$ and for $\kappa$, $\iota(\sigma_0, \sigma_0) = 1$, despite the zero section $\sigma_0$ being a generator of $H_2(M)$ in both cases.