I have verified the following double sum is always an integer for $s$ up to $1000$ via Maple. But I can not prove it. Proofs, hints, or references are all welcome. Thanks!
$$\sum_{m=s}^{2s}\sum_{k=0}^{s} {2s\choose s}{s\choose k}{m\choose k}{k\choose m-s} \frac{1}{(s+1)(2k-1)(2m-2k-1)}$$
What I have known is that:
(1) Every term is not always an integer, but I can prove that ${2s\choose s}{s\choose k}{m\choose k}{k\choose m-s} \frac{1}{(2k-1)(2m-2k-1)}$ is always an integer.
(2) $\sum_{k=0}^{s} {2s\choose s}{s\choose k}{m\choose k}{k\choose m-s} ={2s\choose s}^2{s\choose m-s}$. This combinatorial identity may be helpful to solve this problem.
Note: The following is not a solution but at least a slight structural simplification of OPs binomial expression. This could be helpful to further simplify the expression but also to find a simpler recurrence with similar means as is it presented in the answer of this question by @Michael Stoll at Math Overflow.
First a few preliminaries:
If a closed formula is hard to find, we could try to eliminate or at least simplify the fractions. With simplification I mean a transformation of the fraction which reduces the number of summation indices in it, so that the formula becomes more manageable for further calculations.
Since the Catalan numbers are natural numbers, we will simply denote them by $C_s$ in the following and we will put the focus on the other parts of the expression.
And now the gory details:
We start by introducing the symbol $C_s$ for the Catalan numbers $C_s=\frac{1}{s+1}\binom{2s}{s}$, exchanging the sums and changing the index range of $m$ from $[s,2s]$ to $[0,s]$.
\begin{align*} A(s)&=\sum_{m=s}^{2s}\sum_{k=0}^{s}\binom{2s}{s}\binom{s}{k}\binom{m}{k}\binom{k}{m-s} \frac{1}{(s+1)(2k-1)(2m-2k-1)}\\ &=C_s\sum_{k=0}^{s}\sum_{m=0}^{s}\binom{s}{k}\binom{m+s}{k}\binom{k}{m} \frac{1}{(2k-1)(2m+2s-2k-1)}\\ &=C_s\sum_{k=0}^{s}\binom{s}{k}\frac{1}{2k-1}\sum_{m=0}^{k}\binom{m+s}{k}\binom{k}{m} \frac{1}{2m+2s-2k-1}\tag{3}\\ \end{align*}
Observe, that in (3) the index range of $m$ is $[0,k]$, since $\binom{k}{m}=0$ if $m>k$. Therefore we effectively sum up over a triangular region $0\leq k \leq s,0 \leq m \leq k$ and not over a square $0\leq k,m\leq s$.
Since
$$\frac{1}{2k-1}+\frac{1}{2m+2s-2k-1}=\frac{2(m+s-1)}{(2k-1)(2m+2s-2k-1)}$$
We start with transforming $A_2(s)$ by exchanging the sums:
\begin{align*} A_2(s)&=\sum_{k=0}^{s}\binom{s}{k} \sum_{m=0}^{k}\binom{m+s}{k}\binom{k}{m}\frac{1}{m+s-1}\cdot\frac{1}{2m+2s-2k-1}\\ &=\sum_{m=0}^{s}\sum_{k=m}^{s}\binom{s}{k}\binom{m+s}{k}\binom{k}{m}\frac{1}{m+s-1}\cdot\frac{1}{2m+2s-2k-1} \end{align*}
Next we introduce the index $l:=s-k+m$ and substitute it with the index $k=s-l+m$ by respecting the index range:
\begin{array}{lcl} k=m&\qquad\longrightarrow\qquad &l=s\\ k=s&\qquad\longrightarrow\qquad &l=m \end{array}
We therefore get after substition and exchange of summation: \begin{align*} A_2(s)&=\sum_{m=0}^{s}\sum_{l=m}^{s}\binom{s}{s-l+m}\binom{m+s}{s-l+m} \binom{s-l+m}{m}\frac{1}{m+s-1}\cdot\frac{1}{2l-1}\\ &=\sum_{l=0}^{s}\sum_{m=0}^{l}\binom{s}{s-l+m}\binom{m+s}{s-l+m} \binom{s-l+m}{m}\frac{1}{m+s-1}\cdot\frac{1}{2l-1}\tag{6} \end{align*}
Next observe, that following binomial identities are valid:
\begin{align*} \binom{m+s}{s-l+m}\binom{s-l+m}{m}&=\binom{m+s}{m}\binom{s}{s-l}\\ \binom{s}{l-m}\binom{m+s}{m}&=\binom{l}{m}\binom{m+s}{l} \end{align*}
Using these identity relation in (6) gives:
The inner sum of $A_1(s)$ can therefore be written as: \begin{align*} \sum_{m=0}^{k}&\binom{m+s}{k}\binom{k}{m}\frac{1}{m+s-1}\\ &=\sum_{m=0}^{k}\left[\binom{m+s-1}{k-1}+\binom{m+s-1}{k}\right]\binom{k}{m}\frac{1}{m+s-1}\\ &=\sum_{m=0}^{k}\left[\frac{1}{k-1}\binom{m+s-2}{k-2}+\frac{1}{k}\binom{m+s-2}{k-1}\right]\binom{k}{m}\frac{1}{m+s-1}\\ &=\frac{1}{k-1}\sum_{m=0}^{k}\binom{m+s-2}{k-2}\binom{k}{m}+\frac{1}{k}\sum_{m=0}^{k}\binom{m+s-2}{k-1}\binom{k}{m}\tag{7} \end{align*}
Please note, that the fractions in $A_1(s)$ are already somewhat simplified with regard to the original formulation. We have no longer any fraction dependent by the index of the inner sum.
In order to do so we use a powerful technique based upon Cauchys residue theorem and introduced by G.P. Egorychev (Integral Representation and the Computation of Combinatorial Sums) to compute binomial identies.
\begin{align*} \sum_{m=0}^{k}&\binom{m+s-2}{k-2}\binom{k}{m}\\ &=\sum_{m=0}^{\infty}\binom{m+s-2}{k-2}\binom{k}{m}\tag{8}\\ &=\sum_{m=0}^{\infty}\mathop{res}_u\frac{(1+u)^{m+s-2}}{u^{k-1}} \mathop{res}_z\frac{(1+z)^{k}}{z^{m+1}}\tag{9}\\ &=\mathop{res}_u\frac{(1+u)^{s-2}}{u^{k-1}}\sum_{m=0}^{\infty}(1+u)^m \mathop{res}_z\frac{(1+z)^{k}}{z^{m+1}}\ \tag{10}\\ &=\mathop{res}_u\frac{(1+u)^{s-2}}{u^{k-1}}(2+u)^k\tag{11}\\ &=[u^{k-2}](2+u)^k(1+u)^{s-2}\tag{12}\\ &=[u^{k-2}]\sum_{m=0}^{k}\binom{k}{m}2^mu^{k-m}(1+u)^{s-2}\\ &=\sum_{m=0}^{k}\binom{k}{m}2^m[u^{m-2}](1+u)^{s-2}\\ &=\sum_{m=2}^{k}\binom{k}{m}\binom{s-2}{m-2}2^m \end{align*}
Comment:
In (8) the limit is changed without affecting the sum, since only $0$ is added.
In (9) the residual calculus of formal power series is applied for each binomial coefficient.
In (10) there is some rearrangement to prepare the application of the substitution rule which is used in (11)
In (12) we use the coefficient of operator $[u^n]$ to denote the coefficient of $u^n$ of the sum.
Note: My answer to this question contains a small introductory note to this technique.
Similarly we can show that for $k \geq 1$:
We conclude:
Besides the information about the power of $2$ within $A_1(s)$ we are now prepared for one more simplifiaction.
We observe:
\begin{align*} B_1(s)&=\sum_{k=2}^{s}\binom{s}{k}\frac{1}{2k-1}\frac{1}{k-1} \sum_{m=2}^{k}\binom{k}{m}\binom{s-2}{m-2}2^m\\ &=\sum_{k=2}^{s}\binom{s}{k}\frac{1}{2k-1}\frac{1}{k-1} \sum_{m=2}^{k}\frac{k(k-1)}{m(m-1)}\binom{k-2}{m-2}\binom{s-2}{m-2}2^m\\ &=\frac{1}{s(s-1)}\sum_{k=2}^{s}\binom{s}{k}\frac{k}{2k-1}\sum_{m=2}^{k}\binom{k-2}{m-2}\binom{s}{m}2^m\\ &=\frac{1}{s-1}\sum_{k=2}^{s}\binom{s-1}{k-1}\frac{1}{2k-1}\sum_{m=2}^{k}\binom{k-2}{m-2}\binom{s}{m}2^m\\ \end{align*}
Similarly we get
\begin{align*} B_2(s)&=\sum_{k=2}^{s}\binom{s}{k}\frac{1}{2k-1}\frac{1}{k} \sum_{m=1}^{k}\binom{k}{m}\binom{s-2}{m-1}2^m\\ &=\sum_{k=2}^{s}\binom{s}{k}\frac{1}{2k-1}\frac{1}{k} \sum_{m=1}^{k}\frac{k}{m}\binom{k-1}{m-1}\frac{s-1}{s-1}\binom{s-2}{m-2}2^m\\ &=\frac{1}{s-1}\sum_{k=2}^{s}\binom{s}{k}\frac{1}{2k-1}\sum_{m=1}^{k}\binom{k-1}{m-1}\binom{s-1}{m}2^m\\ \end{align*}