This is supposed to be done with logical identities and the rules for negation with quantifiers.
A-D are the sentences and 1-4 are the negations.
A) ∀x(P(x) ∧ [(∃yP(y)) ∧ (∃yR(x, y)) ⇒ (∃yP(y))])
B) ∀x∀y(¬R(x, y) ∨ ¬P(x))
C) ∀x(P(x) ⇔ ∃yR(x, y))
D) ∀x∀y(P(x) ∧ R(x, y) ⇒ R(y, x))
1) ∃x∃y(P(x) ∧ R(x, y) ∧ ¬R(y, x))
2) ∃x([P(x) ∨ ∃yR(x, y)] ∧ [¬P(x) ∨ ∀y¬R(x, y)])
3) ∃x∃y(P(x) ∧ R(x, y))
4) ∃x¬P(x)
Intuitively, it seems that A and C are supposed to match with one of 2 or 4 and B and D are supposed to match with one of 1 and 3. I might be wrong though.
I have tried to use these basic formulas:
¬∀xP(x) = ∃x¬P(x) and ¬∃xP(x) = ∀x¬P(x)
but the expressions above seem the be much longer and seem to involve far more manipulation.
Any help?

In addition to those quantifier negation rules, you can also use the good old propositional logic equivalences, such as Commutation, Association, DeMorgan's Laws, laws for rewriting biconditionals and conditionals, etc.
For example, let's take B) and negate it:
$$\neg \forall x \forall y (\neg R(x,y) \lor \neg P(x)) \Leftrightarrow \text{ (Quantifier Negation)}$$
$$\exists x \exists y \neg (\neg R(x,y ) \lor \neg P(x)) \Leftrightarrow \text{ (DeMorgan)}$$
$$\exists x \exists y (R(x,y) \land P(x)) \Leftrightarrow \text{ (Commutation)}$$
$$\exists x \exists y (P(x) \land R(x,y))$$
OK, so that matches 3 ... can you do the others?
...
OK, you matched D correctly with 1. I would show a few more steps though:
$$\neg \forall x \forall y ((P(x) \land R(x,y)) \rightarrow R(y,x)) \Leftrightarrow \text{ (Quantifier Negation)}$$
$$\exists x \exists y \neg ((P(x) \land R(x,y)) \rightarrow R(y,x)) \Leftrightarrow \text{ (Implication)}$$
$$\exists x \exists y \neg (\neg (P(x) \land R(x,y)) \lor R(y,x)) \Leftrightarrow \text{ (DeMorgan)}$$
$$\exists x \exists y ((P(x) \land R(x,y)) \land \neg R(y,x))$$
For C, it's a good idea to rewrite the biconditional, since none of 1 through 4 contain a biconditional:
$$\neg \forall x (P(x) \leftrightarrow \exists y R(x,y)) \Leftrightarrow \text{ (Quantifier Negation)}$$
$$\exists x \neg (P(x) \leftrightarrow \exists y R(x,y)) \Leftrightarrow \text{ (Equivalence)}$$
$$\exists x \neg ((P(x) \land \exists y R(x,y)) \lor (\neg P(x) \land \neg \exists y R(x,y)))$$
... can you take it from here?