Let $\Bbb H$ denote the quaternion algebra. We can identify $S^3$ as the subset of unit quaternions. For fixed $q_1,q_2\in S^3$, consider the map $\phi:S^3\to S^3$ defined by $\phi(x)=q_1xq_2^{-1}$. How can we show that if $q_1^2=q_2^2=-1$ (so that $\phi^2=\text{id}$) then $\phi$ has a fixed point?
(This is claimed in a lecture note that I was reading, contained in the sketch of proof of the statement that if $G$ is a subgroup of $SO(4)$ of order $2$ acting freely on $S^3$, then $G=\{\pm \text{id}\}$.)
The map $\phi:x\mapsto q_1x\overline q_2$ is ($\Bbb R$-)linear and as $\phi^2={\rm id}$, its minimal polynomial $m_\phi$ divides $(X^2-1)$.
If $m_\phi=(X-1)$ or $(X^2-1)$, then we're ready because $1$ is an eigenvalue of $\phi$.
The only remaining case is $m_\phi=(X+1)$, i.e. $\phi(x)=-x$.
But in that case $q_1\overline q_2=\phi(1)=-1$ implying $q_2=-q_1$, so $$q_1x\overline q_1=-\phi(x)=x$$ for all $x\in\Bbb H$, or, $q_1x=xq_1$, that is, $q_1$ is in the center of $\Bbb H$, therefore $q_1\in\Bbb R$, namely $q_1=\pm1$, contradicting to $q_1^2=-1$.