If $x_1,x_2,x_3,x_4,x_5$ and $x_6$ are positive real numbers that add up to $2$, then:
$$2^{12} \leq \left(1+\dfrac{1}{x_1}\right) \left(1+\dfrac{1}{x_2}\right)\left(1+\dfrac{1}{x_3}\right)\left(1+\dfrac{1}{x_4}\right)\left(1+\dfrac{1}{x_5}\right)\left(1+\dfrac{1}{x_6}\right) .$$
Factoring out the $\dfrac{1}{x_1}, \ldots, \dfrac{1}{x_6}$ from each term, I get $$\dfrac{1}{x_1}(x_1 + 1)\dfrac{1}{x_2}(x_2 + 1)\dfrac{1}{x_3}(x_3 + 1)\dfrac{1}{x_4}(x_4 + 1)\dfrac{1}{x_5}(x_5 + 1)\dfrac{1}{x_6}(x_6 + 1)$$ We know that: $x_1 + \cdots + x_6 = 2$
Also, I see that $x_1, \ldots, x_6$ are small numbers and $1$ over something small will give something big.
How can I keep going?
The inequality is equivalent to
$$ \frac{1}{ \left(1+\dfrac{1}{x_1}\right) \left(1+\dfrac{1}{x_2}\right)\left(1+\dfrac{1}{x_3}\right)\left(1+\dfrac{1}{x_4}\right)\left(1+\dfrac{1}{x_5}\right)\left(1+\dfrac{1}{x_6}\right)} \leq \frac{1}{2^{12}}$$
or
$$\sqrt[6]{\prod \frac{x_i}{x_i+1}} \leq \frac{1}{4}$$
Now, by AM-GM we have
$$\sqrt[6]{\prod \frac{x_i}{x_i+1}} \leq \frac{\sum \frac{x_i}{x_i+1}} {6}$$, so it suffices to prove
$$\sum \frac{x_i}{x_i+1} \leq \frac{3}{2}$$
This is equivalent to
$$6- \sum \frac{1}{x_i+1} \leq \frac{3}{2} \Leftrightarrow \sum \frac{1}{x_i+1} \geq \frac{9}{2}$$
But this is Just Cuachy Schwartz
$$6^2 \leq \left( \sum \frac{1}{x_i+1} \right) \left(\sum (x_i+1)\right)=\left( \sum \frac{1}{x_i+1} \right) \left(2+6\right)$$