Given a set $X\subset\Bbb R^n$ (I am most interested in $n=4$) that is homeomorphic to the $n$-ball $B^n:=\{x\in\Bbb R^n\mid \|x\|\le 1\}$. Is it true that the boundary $\partial X$ is homeomorphic to the $(n-1)$-sphere $S^{n-1}:=\partial B^n$?
This sounds like an inverse of the generalized Schönflies theorem, but I haven't found anything on this.
This follows from invariance of domain. Let $f:B^n\to X$ be a homeomorphism and let $U$ be the interior of $B^n$. Then $f(U)$ is a subset of $\mathbb{R}^n$ homeomorphic to $\mathbb{R}^n$, so it is open in $\mathbb{R}^n$ by invariance of domain. Thus $\partial X\subseteq f(\partial B^n)$. For the reverse inclusion, if $x$ is in the interior of $X$, then $x$ has a neighborhood in $X$ which is homeomorphic to $\mathbb{R}^n$, so $f^{-1}(x)$ has a neighborhood in $B^n$ which is homeomorphic to $\mathbb{R}^n$, which implies $f^{-1}(x)\in U$ (for instance, by invariance of domain considering $B^n$ as embedded in $\mathbb{R}^n$). So $\partial X=f(\partial B^n)$ and is homeomorphic to $\partial B^n$ via $f$.