I am a middle school student who would really appreciate it if somebody could explain how to solve this problem using simple terms. I saw this problem on this site and one other, but I am still unsure of how to get $384$ like the solution said here: Mini Sudoku -Critique of Solution-
In this circumstance -with $16$ available slots- there are $384$ possible combinations with over-counting.
And here is the problem:
Let's play mini-Sudoku!
We wish to place an $X$ in four cells, such that there is exactly one $X$ in each row, column, and $2\times2$ outlined box. For example:
In how many ways can we do this?
Terminology: A cell is one of small $1\times1$ spaces. A box is one of four outlined $2\times2$ group of cells. Please use this terminology so there is no ambiguity between you and your audience.

You can put an $X$ in any one of the four cells in the upper left box. You then have two choices in the upper right box and two choices in the lower left box because of the row/column requirement. The placing in the lower right box is fixed, so there are $16$ different patterns. If you distinguish the order you place the $X$s this multiplies the number by $4!=24$. $16 \times 24=384$ as claimed.