Is there a way to integrate a binomial coefficient? I've tried to put the following into Wolfram Alpha, but it doesn't return a result. I have a small suspicion that I'm going a bit over my head here, but does anyone know if this is even possible?
$$F(n) = \int_1^n \binom{n}{x} \,dx$$
For integer $n, x$ we have $${n \choose x} = \frac{n!}{x! (n - x)!} = \frac{\Gamma(n + 1)}{\Gamma(x + 1) \Gamma(n - x + 1)},$$ where $\Gamma$ is the Gamma function, and the rightmost expression is defined for most values of $n, x$, including for all values of $x$ in the interval $[1, n]$ of integration, when $n$ is a positive integer, so we can interpret $n \choose x$ as taking on that value.
If $n$ is a nonnegative integer, using the identity $\Gamma(z + 1) = z \Gamma(z)$ (cf. the factorial identity $n! = n (n - 1)!$) and the Euler Reflection Formula, $$\Gamma(1 - z) \Gamma(z) = \frac{\pi}{\sin \pi z} ,$$ gives that $${n \choose x} = - \frac{n! \sin \pi (x + 1)}{\pi x (1 - x) \cdots (n - x)} .$$ Now, decomposing using the method of partial fractions lets us rewrite this expression as $$\frac{\sin \pi (x + 1)}{\pi} \sum_{k = 0}^n (-1)^k {n \choose k} \frac{1}{k - x} ,$$ so that the original integral is $$\int_1^n {n \choose x} \,dx = \frac{1}{\pi} \sum_{k = 0}^n (-1)^k {n \choose k} \int_1^n \frac{\sin \pi (x + 1) \,dx}{k - x}.$$
Now, substituting $u = k - x$ gives $$\int_1^n \frac{\sin \pi (x + 1) \,dx}{k - x} = (-1)^{k + 1} \int_{k - 1}^{k - n} \frac{\sin \pi u}{u} \,du = (-1)^k [\operatorname{Si}(\pi (k - n)) - \operatorname{Si}(\pi (k - 1))],$$ where $\operatorname{Si}$ is the sine integral function. After reorganizing and applying a binomial identity we get $$\boxed{\int_1^n {n \choose x} \,dx = \frac{1}{\pi} \left[\left(\frac{1}{2} n (n + 1) - 1\right) \operatorname{Si}(\pi) + \sum_{j = 2}^n {{n + 1} \choose {j + 1}} \operatorname{Si}(\pi j) \right]}.$$
For example, for $n = 2$ we have $$\int_1^2 {2 \choose x} \,dx = \frac{2 \operatorname{Si}(\pi) + \operatorname{Si}(2 \pi)}{\pi} = 1.63039\ldots,$$ and for $n = 3$, $$\int_1^3 {3 \choose x} \,dx = \frac{5 \operatorname{Si}(\pi) + 4 \operatorname{Si}(2 \pi) + \operatorname{Si} (3 \pi)}{\pi} = 5.28618\ldots.$$
Remark 1 It would be more symmetric to consider $\int_0^n {n \choose x} \,dx$, since $n \choose x$ and hence the integral is fixed under the change $x \mapsto n - x$, yielding the simpler formula $$\int_0^n {n \choose x} \,dx = \frac{2}{\pi} \sum_{j = 1}^n {n \choose j} \operatorname{Si}(\pi j) .$$ Notice that for $n = 1$ we get $\int_0^1 {1 \choose x} \,dx = 2 \operatorname{Si}(\pi)$, so twice the Wilbraham-Gibbs constant, which arises in the Gibbs phenomenon in Fourier analysis and signal processing.
Remark 2 Heuristically, we should expect that for large $n$, $\int_1^n {n \choose x} \,dx \approx \sum_{k = 0}^n {n \choose k} = 2^n$. Already for $n = 16$ we have $F(n) = 65529.67158\ldots \approx 65536 = 2^{16}$, a relative error of $< 10^{-4}$.