We are given $x_0 = 1, x_1 = \frac{4}{3}$ and $x_2 = 2$. Find a parabola which agrees with function $f(x) = (x + 1)\sin(x)$ in the given points. Afterwards derive a formula for the approximation of the $f'$ i.e. the derivative in $x_1$. What is the approximation of $f'(x_1)$ for function f?
I did the first step using interpolation and got the polynomial $p(x) = -1.0647x^2 + 4.2390x - 1.4914.$ Now I do not know how to use this to approximate the derivative. Should I just compute the derivative of the polynomial $p$? What about the approximation then?

$$ f\left(x \right) = \left(x + 1\right)\sin x \implies \left\lbrace \begin{alignedat}{4} f\left(x_0\right)&= 2\sin \left(1\right) &&\approx 1.68,\qquad &\text{where} \quad x_0&=1 \\ f\left(x_1\right)&= \tfrac{7}{3}\sin \left(\tfrac{4}{3}\right)&\, &\approx 2.27, &\text{where} \quad x_1&=4/3 \\ f\left(x_2\right)&= 3\sin \left(2\right) &&\approx 2.73,& \text{where} \quad x_2&=2& \\ \end{alignedat} \right. $$
The general form of equation of parabola is $$ y-\widehat{y} = k\left(x-\widehat{x}\right)^2\qquad \text{ or }\qquad y\left(x\right) = ax^2+bx+c $$
Substituting known values we get system of equations
$$ \left\lbrace\begin{aligned} y\left(x_0\right) =f\left(x_0\right)\\ y\left(x_1\right) =f\left(x_1\right) \\ y\left(x_2\right) =f\left(x_2\right) \end{aligned}\right. \implies \left\lbrace\begin{aligned} ax_0^2+bx_0+c &= 2\sin \left(1\right) \\ ax_1^2+bx_1+c &= \tfrac{7}{3}\sin \left(\tfrac{4}{3}\right) \\ ax_2^2+bx_2+c &= 3\sin \left(2\right) \\ \end{aligned}\right. \iff \left\lbrace\begin{aligned} a+b+c & \approx 1.68 \\ \tfrac{16}{9}a+\tfrac{4}{3}b+c &\approx 2.27 \\ 4a +2b+c &\approx 2.73\\ \end{aligned}\right. $$
Solving the last system of linear equations for coefficients $a,b$, and $c$ will give you general form of parabola.
As for approximating derivatives, I recommend following advise of @caverac and using Divided differences, or use straightforward Finite difference formula
$$ f'\left(x_1\right)\approx\frac{f\left(x_2\right)-f\left(x_0\right)}{x_2-x_0} = \frac{2\sin 1 -3\sin 2}{1}\approx -1.045 $$