Prove that $x^4-32x^3+240x^2-320x-368=0$ is irreducible over $\mathbb{Z}$
My working :I've tried using Perron's irreducibility criterion but not applicable here, tried Cohn's irreducibility criterion and also tried Eisenstein's criterion but could not found any prime $p$ \begin{align*} 32&=2^5\\240&=2^4\times 3\times 5\\320&=2^6\times 5\\368&=2^4\times 23\end{align*}
Try some substitutions. First: since you have coefficients involving high powers of $2$, put in $x=2y$. After dividing out a common factor of $16$ you get
$y^4-16y^3+60y^2-40y-23=0.$
This is almost $2$-Eisenstein, except the final coefficient is odd.
To remove that defect, try an odd increment, $y=z+\text{an odd number}$. I find that $y=z+1$ gives an equation for $z$ that is fully $2$-Eisenstein, and irreducibility is proved.