A measure is locally finite if it is finite on all compact sets from the underlying $\sigma$-algebra.
A measure is regular if every measurable set $A\in\Sigma$ can be approximated from above by open measurable sets: $$ \mu(A)\,=\,\operatorname{inf}\,\left\{\,\mu(O)\;\Big{|}\;A\subseteq O\;,\;\;O\in\Sigma\,,\;\,O\;\,\mbox{open} \,\right\}\;\;,\;\; $$ and from below by compact measurable sets: $$ \mu(A)\,=\,\operatorname{sup}\,\left\{\,\mu(C)\;\Big{|}\;C\subseteq A\,,\;\,C\in\Sigma\,,\;\,C\;\,\mbox{compact}\,\right\}\;\;. $$
A Radon measure is a Borel measure that is introduced on the Borel algebra of a Hausdorff topological space, and is regular and locally finite.
Question 1: $\;\;$is a non-zero Radon measure always positive on non-empty open sets?
Question 2: $\;\;$the same for a non-zero Haar measure
Unless I'm overlooking something trivial, the answer is no. Look at the "restriction" of Lebesgue measure $\lambda$ on $\Bbb{R}$ to $[0,1]$, by which I mean $\mu(E):= \lambda(E\cap [0,1])$. Then, $\mu$ is a finite Borel measure on $\Bbb{R}$, hence is regular, but the open set $(10,11)$ has measure $0$ with respect to $\mu$.