In the process of a topology course, it occurred to me that a number of concepts are defined with reference to $\mathbb{R}$ and standard subsets thereof. For instance, we consider metrics, which are of course maps into $\mathbb{R}$ (specifically the non-negatives, but still). We devote a chapter of a book to the concept of path-connectedness, i.e. a way of expressing (part of) a space as a continuous image of a closed real interval. We define separation axioms according to the ability to separate particular sets with continuous maps into closed intervals.
A lot of concepts in topology are defined with reference to particular subspaces of $\mathbb{R}$. But move to other fields, say measure theory, and the entire branch is defined by functions into $\mathbb{R}$.
I suppose my question is: To what extent is our interest in objects "founded on" $\mathbb{R}$ simply a matter of our massive familiarity with $\mathbb{R}$, and to what extent do these concepts draw on characteristics really constitutive of $\mathbb{R}$? Put another way, do we tend to consider real-based objects because the reals are "intuitive", or because $\mathbb{R}$ (or its relevant subsets) has particularly special properties that we don't really find in other (truly distinct*) objects?
*By "truly distinct", I mean to preempt answers along the lines of, "Well you can construct this thing which isn't the set $\mathbb{R}$ per se, but is still for all intents and purposes the exact same thing as $\mathbb{R}$."
I think you can definitely try and make a distinction between fields of mathematics that are "founded on $\mathbb{R}$" in a strong sense and those that aren't (but in which our familiarity with $\mathbb{R}$ and its cousins might play and important role in terms of providing examples, intuition, driving questions, etc).
Consider the following fields:
Now, regarding general topology, I would like to argue that while it has many applications to objects that are "founded on $\mathbb{R}$" and fields that are founded on $\mathbb{R}$ in a strong sense (such as manifold theory), it is, not, per se, a field that is founded on $\mathbb{R}$ and the real numbers don't play a particularly important role.
The basic players in topology are defined using an abstract family of axioms (very much like in group theory). By imposing additional restrictions (separation axioms, again, defined in terms of the basic operations), we can single out specific classes of topological spaces. For example, one might define a family of spaces that are regular, Hausdorff and have countably locally finite basis and investigate their properties. It turns out by the Nagata-Smirnov metrization theorem that such spaces are precisely the topological spaces that admit a metric but a priori we can investigate the topological properties of such spaces without introducing a metric at all. Choosing a metric on such a space can be considered as introducing an "axillary" data that helps us (as we are familiar with the real numbers and properties of distance in Euclidean spaces) to analyze the family and describe its topological properties.
Regarding path-connectedness, the amazing answer of Eric to this question shows that the notion of path-connectedness can also be defined without introducing the interval $[0,1]$ and using the interval to define a path can be considered as introducing "axillary" data that helps us to visualize, give intuition and analyze path-connected spaces.
Of course, the history went the other way and we care about paths because we visualize them as generalization of paths in an Euclidean space and we care about seperation axioms because we care about metric spaces and want to understand which parts that hold in metric spaces can be "abstracted away" but once the abstraction has been done, the real numbers stop playing a foundational role.