Consider following polynomials: \begin{align} P_n(x)&=x^{2n-1}-\sum_{i=0}^{n-1}2\binom{2n}{2i+1}x^{2i} \end{align} for $n\geq 1$. Can we prove they are irreducible over $\mathbb{Q}$?
So first couple are $$x-4$$ $$ x^3-8x^2-8$$ $$ x^5-12x^4-40x^2-12$$ $$ \dots$$
For small specific values of $n$ we can prove it, for example for $x^3-8x^2-8$ we only need to check for linear factor, specifically for roots $\pm 1,\pm2,\pm4\pm 8$. With Maple I've verified more than first $600$ values of $n$ so far, all appear to be irreducible (using the irreduc function).
However for general $n$ I have no idea how to go about this, the Eisenstein criterion cannot be directly used, so I've tried substitutions like $P_n(x\pm 1)$, but it does not help.
Edit: Just out of curiosity, I have tried to change the polynomial a bit to see when it stops to be irreducible (again for small values of $n$, let's say to $100$) and I found it interesting that you can do quite a lot changes and it still remains irreducible. For example replacing the multiple of $2$ by other integers, or changing signs of the individual terms in sum, or even replace $2i+1$ in binomial coefficients with $2i$. What is going on?
For odd $n$ the irreducibility of these polynomials follows from a generalization of Eisenstein's criterion known as Newton's polygon applied to the prime $p=2$.
When $n$ is odd the constant term $4n$ is divisible by four but not divisible by eight. Furthermore, Lucas' theorem tells us that all the binomial coefficients $\binom {2n}{2i+1}$ are even, implying that all the other coefficients, save for the leading $1$, are also all divisible by four (and possibly by a higher power of two). These imply that the Newton's polygon consists of a single line segment from $(0,2)$ to $(2n-1,0)$. The slope of this line is $-2/(2n-1)$ implying that the line segment does not pass through any integer points other than its endpoints. By $2$-adic theory this guarantees that $P_n(x)$ is irreducible over the $2$-adic field $\Bbb{Q}_2$ and hence also over the subfield $\Bbb{Q}$.
The case of an even $n$ is more complicated but it may be possible study the divisibility of the coefficients by powers of two and again settle the claim. For example the Newton's polygon of $$ P_4(x)=x^7-16(x^6+7x^4+7x^2+1) $$ is the line segment from $(0,4)$ to $(7,0)$, has slope $-4/7$, and the same argument goes through.