As simple as that: Can we find an irreducible polynomial in $\mathbb{Q}$ such that, if $K$ is its splitting field over $\mathbb{Q}$, $\operatorname{Gal}(K|\mathbb{Q})\cong S_4$?
I've thought a lot and I have not reached any. Can you give me a hand please?
Following @user64687's hint in the comments, thus according to Keith Conrad's notes, a degree-$4$ polynomial from $K[X]$, where $K$ is a field with $\operatorname{char}K\not\in\{2,3\}$, has Galois group $S_4$ if
In example 3.2, Keith Conrad shows that the Galois group of $f(X) = X^4 - X - 1$ over $\mathbb{Q}$ is $S_4$. Let me demonstrate the very similar case $$f(X) = X^4 + X + 1$$ instead. Since $f(X) - (X^{2^2}-X) = 1$ in $\mathbb{F}_2[X]$, $f(X)$ is coprime to every irreducible polynomial over $\mathbb{F}_2$ of degree dividing $2$, this implies that $f(X)$ is irreducible $\bmod{2}$, thus $f(X)$ is irreducible over $\mathbb{Q}$. Therefore its Galois group has order divisible by $4$.
$f(X)$ has the resolvent cubic $$g(X) = X^3 - 4 X - 1$$ which, by its low degree and the rational root theorem, would need to have an integer root dividing $1$ if it were reducible over $\mathbb{Q}$, but it hasn't, so $g(X)$ is irreducible over $\mathbb{Q}$. The extension degree of the splitting field of $g(X)$ over $\mathbb{Q}$ is therefore divisible by $3$. By construction of the resolvent cubic, the splitting field of $g(X)$ is contained in the splitting field of $f(X)$, so the order of the Galois group of $f(X)$ must be divisible by $3$.
Again by construction, the discriminant of $f(X)$ equals the discriminant of $g(X)$, which is $$\Delta=229$$ and is thus easily recognizable as a nonsquare in $\mathbb{Q}$. In particular, it's congruent to the nonsquare $5\pmod{8}$.
Summarizing the above results, the Galois group of $f(X)$ has order divisible by $3$ and $4$, yet is not a subgroup of $A_4$. This leaves $S_4$ as only possible Galois group for $f(X)$.
If you are looking for a quartic polynomial with only real roots, see here; the argumentation there is almost the same.