$2^2$ is between the twin primes $3$ and $5$. Are there any other instances of a power of two between twin primes? If so, how many?
That there are Mersenne primes (primes of the form $2^n-1$) makes this a little more tantalizing, but a brief search didn't spit out any results right away.
No: if $n$ is odd, $3\mid 2^n+1$, and if $n$ is even, $3\mid 2^n-1$.
To see this, note that $2^n+1=2^n+1^n$, which is divisible by $2+1$ if $n$ is odd, while $2^{2k}-1=4^k-1^k$ is divisible by $4-1$.