Consider the following directed graphs:

One is obtained from the other by reversing the direction of all edges.
Are they isomorphic as directed graphs ?
On the one hand, I would answer: no because there is no pair of maps between the vertices and the edges respectively that preserves the adjacency relation.
On the other hand, if one forgets about the ``labels'' on say, the edges, then the graphs are the same (just exchange the label 'e' with label 'f').
Your comment helps clarify the source of your confusion:
You implicitly (and wrongly) assume that edge $f$ in the left graph is the same as edge $f$ in the right graph. The confusion is only due to name clash. Renaming should save you from this mistake.
If we named edges in the right graph $e'$ and $f'$, then instead of writing this statement (original):
we would have written this statement: