Let $$F\left(x\right)=\int_{t^2}^{x^3}{\frac{\mathrm{d}y}{\sqrt{x^2+y^4}}}$$ Find $F'\left(x\right)$
Had the lower limit been a function of $x$ I would have easily calculated. I am not very familiar with the Newton-Leibniz rule in two variables. I do not know which formula to use.
You can use the most general one. The below is from Wikipedia.
So actually because the lower limit of the integral is a function of $t$ and because you are differentiating with respect to $x$, you can treat $t^2$ as a constant. And you can change the integrating variable, and for the purpose of preventing confusion let's change it to $t'$. Notice that the $t$ inside the integral is independent of the $t^2$ in the lower limit.
$$F_t(x) = \int_{a(t)}^{b(x)} g(x, t') \ dt'$$
$$\frac{\partial F_t(x)}{\partial x} = g(x, b(x)) \times \frac{\partial b}{\partial x} \ + \ g(x, a(t)) \times \frac{\partial a(t)}{\partial x} + \int_{a(t)}^{b(x)} \frac{\partial g(x, t')}{\partial x} dt'$$
If we plug in everything we get
$$f_t(x) = \frac{3x^2}{\sqrt{x^2 + x^6}} - \ 0 \ -\frac{1}{2} \int_{t^2}^{x^3} (t'^4 + x^2)^{-3/2} dt'$$
I couldn't integrate the last term, so you may try it out.
What's important here is to think about the intuition behind the formula - think of it as a proper generalisation and combining of the two formulae:
$$\frac{d}{dx} \int_a^x f(t) dt = f(x) \Rightarrow \frac{d}{dx} \int_{a(x)}^{b(x)} f(t) dt = f(b(x)) \times \frac{db}{dx} - f(a(x)) \times \frac{da}{dx}$$ (which is a simple use of chain rule)
$$\frac{d}{dx} \int_a^b f(x, t) \ dt = \int_a^b \frac{\partial f(x, t)}{\partial x} \ dt$$