Call $(S_i)_{i=1}^{\infty}$ a Gilbreath sequence if $1=\lvert S_2-S_1\rvert=\lvert \lvert S_3-S_2\rvert-\lvert S_2-S_1\rvert\rvert=\cdots$, i.e., if the sequence can be substituted for the primes in Gilbreath's conjecture.
Let $g_n^k=p_{n+k}-p_n$, where $p_n$ is the $n$th prime. Do there exist twin primes $p_{k+1},\ p_{k+2}$ such that $g_1^k,g_2^k,\ldots$ is a Gilbreath sequence? That there exists some such $k$ is a generalization of Gilbreath's conjecture, since it is the case $k=1$.
To give a simple example, it appears that we can take $k=2$, which has the sequence of gaps $5-2=3,\ 7-3=4,\ 11-5=6,\ 13-7=6,17-11=6,\ 19-13=6,\ldots,$ which have absolute differences $1,2,0,0,0,\ldots$
Till now, I cannot tell you for which $k$ the sequence is Gilbreath. But at least I can tell you for which $k$ it is not Gilbreath.
It was a hard attempt for my laptop CPU to test 50000 sequences for k from 1 to 100 which took 231.3s time.
I obtained the following results:
Running the following C++ code:
If you believe this code needs an improvement, you may alter it on github.
I hope some one can give you a better idea.