I came across a puzzle. You start with number $1$. You have to add $2,3,5$ and multiply by $2,3,5$. All $6$ operations must be done exactly once. And outcome must be $49$.
Tried many combinations. But closest I came is $48$ or $50$. I suspect that only even number will come out. But I cannot explain.
I wrote a Python program to brute-force all possible permutations of the operations and see whether they resulted in $49$:
It returned no solutions. So the problem with $2,3,5$ is unsolvable.
If the fives are changed to fours, however, there is a unique solution: $((1×4+2)×2+3)×3+4 = 49$.